Recent advancements in instrumentation technologies have enabled researchers to accurately measure biomolecules participating in giving rise to complex biological phenomena such as cancer, diabetes and drug resistance. Towards developing a mechanistic understanding of such complex biomolecular processes and to decipher the exact role of specific biomolecular entities within them, data integrative approaches can be quite helpful. The Biomedical Informatics & Engineering Research Laboratory (BIRL) at LUMS, Pakistan, aims to address such bio-medical informatics challenges by leveraging data integrative approaches that cut across disciplines. Specifically, we develop mathematical models of multifactorial systems, simulation software, and data analysis pipelines. Current themes of research at BIRL span (i) Systems Biology, (ii) Proteogenomics, (iii) Health Informatics, and (iv) Targeted Drug Development for “Scientific Wellness”. We love to hear from colleagues working in these areas! If you are interested in leveraging our high-performance computing facilities, please ping us. We will be glad to assist you!